報告題目：Statistical genetics in and out of quasi-linkage equilibrium
報告人：Erik Aurell教授
報告人單位：瑞典皇家理工大學
報告時間：2023年8月14日15:30-16:30
報告地點：教2-314會議室
報告內容：
This talk is about statistical genetics, an interdisciplinary topic between statisticaphysics and population biology. The focus is on the phase of quasi-linkage equilibrium(OLE). Our goals here are to clarify under which conditions the OLE phase can beexpected to hold in population biology and how the stability of the OlE phase is lostThe OLE state.which has many similaritiesthermal equilibrium state intoastatistical mechanics, was discovered by Kimura for a two-locus two-allele model. andwas extended and generalized to the global genome scale by Nether and Shraiman(2011). What we will refer to as the Kimura-Neher-Shraiman theory describes apopulation evolving due to the mutations. recombination, natural selection andpossibly genetic drift.A OLE phase exists at suffciently high recombination rate andor mutation rates with respect to selection strength.We showhowin OLEitispossible to infer the epistatic parameters of the fitness function from the knowledge ofthe (dynamical) distribution of genotypes in a population. We further consider thebreakdown of the OLE regime for high enough selection strength. We review recentresults for the selection-mutation and selection-recombination dynamics. Finally. weidentify and characterize a new phase which we call the non-random coexistencewhere variability persists in the population without either fixating or disappearing.
報告人簡介：
Erik Aurell教授，1989年博士畢業于瑞典哥德堡大學理論物理專業，隨后分別在法國巴黎理論物理研究所、美國康內爾大學、瑞典斯德哥爾摩大學、北歐物理研究所等機構擔任研究員，從事非線性科學、隨機組合優化、非平衡統計物理、生物信息學等諸多方向的研究。2003年起，擔任瑞典皇家理工大學生物物理系Chair教授，同時任芬蘭杰出教授(瑞典皇家理工大學-芬蘭阿爾托大學聯合教授)，中國科學院客座教授等。目前，Aurell教授發表專業論文近300篇，其中多篇發表于PRL、PNAS等具有重要國際影響的學術期刊上，是國際統計物理學界的知名學者。近年來，Aurell教授發展了統計物理反問題的相關研究方法和理論，并成功應用于基因序列共演化等實際體系，取得了很有意義的成果。